AA1 – Life Science

Project

AA1-11*

Receptor dynamics and interactions in complex geometries: an inverse
problem in particle-based reaction-diffusion theory

Project Heads

Paolo Annibale, Martin Lohse, Christof Schütte

Project Members

Horst-Holger Boltz

Project Duration

01.01.2021 − 31.12.2021

Located at

ZIB

Description

Building on an existing incubator project, we will extend our spectroscopy of single molecule interaction times, a highly relevant inverse particle-based reaction diffusion problem in cell biology, to more complex membrane geometries as well as dynamics of the particles on the membrane. This reflects (i) the often peculiar geometries encountered in more specialized cell types, and (ii), the substantial compositional heterogeneity of the cell membrane, leading to complex and diverse types of motion. In particular, we shall investigate how membrane curvature and anisotropy thereof can affect the dynamics and downstream coupling of seven transmembrane receptors (GPCRs).

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