IN – Track B



Determining the probability distribution function of molecular overlap times in single molecule microscopy: random collisions and constructive interactions

Project Heads

Paolo Annibale, Martin Lohse, Christof Schütte

Project Members

Horst-Holger Boltz (ZIB)

Project Duration

Located at


When imaged under a microscope, fluorescently labeled receptor molecules on the plasma membrane of the cell appear as diffraction limited spots. These molecules and the corresponding microscopic spots diffuse and can interact depending on their relative affinity. Collisions among them may result either in random overlaps or in constructive interaction and therefore overlap of varying duration. While it is experimentally possible to extract overlap times with relative ease, modeling of these processes based on the underlying reaction-diffusion laws has received considerably less attention and would represent an important tool to characterize and assess molecular interactions at the cell surface.

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