Martin Lohse, Marcus Weber, Christof Schütte, Christoph Stein
Vikram Sunkara (FU), Noureldin Saleh (till August 2019, ZIB), Sourav Ray (from January 2020, ZIB)
01.01.2019 – 31.12.2021
FU Berlin / ZIB
Opioid receptors play a major role in the treatment of severe pain. The project aims at accurate spatio-temporal modelling and simulation of intracellular signaling cascades initiated by opioid receptors, such as G-proteins, ion channels, cAMP, and the arrestin complex in order to design, e.g., non-addictive pain treatments.
A German documentary about pain relief can be accessed here. M. Weber and C. Stein have contributed to this ARTE TV documentary in 02/2020.
M. Weber and C. Stein have presented a common outreach talk at URANIA in 03/2020. The link is here.
There is a ZIB webpage about this project here.
A website showing the clinical relevance and the experimental anesthesiology approach at Charité can be found here.
Different binding modes at only one pH value
Simulation of protonation states
We were able to explain the outcome of clinical tests on the basis of this dependence.
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