Project Heads
Martin Lohse, Marcus Weber, Christof Schütte, Christoph Stein
Project Members
Vikram Sunkara (FU), Noureldin Saleh (till August 2019, ZIB), Sourav Ray (from January 2020, ZIB)
Project Duration
01.01.2019 – 31.12.2021
Located at
FU Berlin / ZIB
Opioid receptors play a major role in the treatment of severe pain. The project aims at accurate spatio-temporal modelling and simulation of intracellular signaling cascades initiated by opioid receptors, such as G-proteins, ion channels, cAMP, and the arrestin complex in order to design, e.g., non-addictive pain treatments.
Project Webpages
A German documentary about pain relief can be accessed here. M. Weber and C. Stein have contributed to this ARTE TV documentary in 02/2020.
M. Weber and C. Stein have presented a common outreach talk at URANIA in 03/2020. The link is here.
There is a ZIB webpage about this project here.
A website showing the clinical relevance and the experimental anesthesiology approach at Charité can be found here.
Selected Publications
Review Articles:
Book Chapters:
Selected Pictures
Different binding modes at only one pH value
Simulation of protonation states
We were able to explain the outcome of clinical tests on the basis of this dependence.
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