Project
AA-Health-4
Modeling Synaptic Plasticity: A Data-Driven Approach to Neurotransmission Dynamics
Project Heads
Manuel Landstorfer, Christof Schütte, Stephan Sigrist, Stefanie Winkelmann
Project Members
Anastasia Bankowski
Project Duration
01.07.2025 − 30.06.2028
Located at
ZIB
Description
This project explores the role of functional proteins in presynaptic neurotransmission and synaptic plasticity using hybrid data-driven and theory-driven models. Focused on parameter estimation and identifiability, it aims to understand synaptic function, neurodegeneration, and sleep deprivation effects.
External Website
Related Publications
Ernst, A., Bankowski, A., Jusyte, M., Okunola, T., Petrov, T., Walter, A. M., & Winkelmann, S. (2025). Parameter Optimization for a Neurotransmission Recovery Model: A. Ernst et al. Bulletin of Mathematical Biology, 87(8), 109.
Related Pictures
Reduced modeling scheme of presynaptic vesicle cycle.
Under the influence of calcium ions and functional proteins, vesicles dock at the active zone of the presynaptic terminal, fuse in response to stimulation, and are then recycled for subsequent use.